Moussa B H Youdim Selected Research

Oxyquinoline (8 Hydroxyquinoline)

6/2014	Donepezil + propargylamine + 8-hydroxyquinoline hybrids as new multifunctional metal-chelators, ChE and MAO inhibitors for the potential treatment of Alzheimer's disease.
8/2012	Multi-target, neuroprotective and neurorestorative M30 improves cognitive impairment and reduces Alzheimer's-like neuropathology and age-related alterations in mice.
1/2012	M30, a brain permeable multitarget neurorestorative drug in post nigrostriatal dopamine neuron lesion of parkinsonism animal models.
1/2010	Restoration of nigrostriatal dopamine neurons in post-MPTP treatment by the novel multifunctional brain-permeable iron chelator-monoamine oxidase inhibitor drug, M30.
1/2010	Propargylamine containing compounds as modulators of proteolytic cleavage of amyloid-beta protein precursor: involvement of MAPK and PKC activation.

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Moussa B H Youdim Research Topics

Disease

75	Parkinson Disease (Parkinson's Disease) 10/2021 - 01/2002
62	Neurodegenerative Diseases (Neurodegenerative Disease) 11/2018 - 01/2002
54	Alzheimer Disease (Alzheimer's Disease) 01/2022 - 01/2002
30	Neuroblastoma 01/2017 - 01/2002
16	Dementia (Dementias) 03/2013 - 03/2002
16	Parkinsonian Disorders (Parkinsonism) 01/2012 - 08/2002
15	Hypoxia (Hypoxemia) 01/2017 - 01/2005
11	Inflammation (Inflammations) 01/2017 - 08/2004
9	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2017 - 03/2004
7	Schizophrenia (Dementia Praecox) 01/2017 - 06/2006
7	Lewy Body Disease (Lewy Body Dementia) 09/2011 - 05/2003
6	Cognitive Dysfunction 01/2017 - 03/2004
6	Neoplasms (Cancer) 04/2013 - 11/2006
6	Pheochromocytoma 01/2012 - 01/2002
5	Neuroinflammatory Diseases 10/2017 - 01/2016
5	Mitochondrial Diseases (Mitochondrial Disease) 02/2016 - 01/2007
5	Disease Progression 09/2011 - 01/2003
5	Huntington Disease (Huntington's Disease) 09/2007 - 03/2004
4	Ischemia 03/2013 - 01/2005
4	Nervous System Diseases (Neurological Disorders) 10/2008 - 03/2004
4	Friedreich Ataxia (Friedreich's Ataxia) 02/2006 - 02/2004
3	Amyloid Plaque 01/2022 - 05/2012
3	Memory Disorders (Memory Loss) 01/2016 - 09/2012
3	Cardiovascular Diseases (Cardiovascular Disease) 05/2011 - 11/2006
3	Craniocerebral Trauma (Head Injury) 06/2005 - 01/2005
2	Retinitis Pigmentosa (Pigmentary Retinopathy) 10/2021 - 10/2017
2	Depressive Disorder (Melancholia) 11/2018 - 01/2006
2	Brain Ischemia (Cerebral Ischemia) 12/2013 - 03/2004

Drug/Important Bio-Agent (IBA)

62	IronIBA 01/2022 - 01/2002
43	rasagiline (Azilect)FDA Link 11/2018 - 04/2002
43	Pharmaceutical PreparationsIBA 01/2018 - 03/2002
40	Monoamine Oxidase (MAO)IBA 01/2022 - 04/2002
34	Chelating AgentsIBA 01/2022 - 03/2004
31	Neuroprotective AgentsIBA 10/2017 - 01/2002
31	Proteins (Proteins, Gene)FDA Link 01/2017 - 08/2002
19	(N-propargyl-(3R) aminoindan-5-yl)-ethyl methyl carbamateIBA 03/2013 - 03/2002
18	AntioxidantsIBA 11/2018 - 01/2002
18	NeurotoxinsIBA 01/2014 - 08/2002
18	PolyphenolsIBA 12/2012 - 01/2002
17	TeaIBA 12/2012 - 01/2002
14	Amyloid (Amyloid Fibrils)IBA 01/2022 - 08/2002
14	Monoamine Oxidase Inhibitors (Monoamine Oxidase Inhibitor)IBA 11/2018 - 12/2002
13	Cholinesterases (Cholinesterase)IBA 01/2022 - 10/2002
13	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 03/2015 - 10/2002
11	Reactive Oxygen Species (Oxygen Radicals)IBA 10/2016 - 03/2004
10	propargylamineIBA 09/2017 - 04/2005
10	Dopamine (Intropin)FDA LinkGeneric 01/2017 - 04/2003
9	MetalsIBA 01/2022 - 09/2004
8	Selegiline (E250)FDA LinkGeneric 11/2018 - 04/2002
8	Oxidopamine (6 Hydroxydopamine)IBA 03/2015 - 01/2002
8	N-propargylIBA 08/2012 - 04/2002
7	Antidepressive Agents (Antidepressants)IBA 11/2018 - 03/2002
7	Therapeutic UsesIBA 01/2017 - 12/2006
7	UbiquitinIBA 01/2012 - 08/2004
6	Complementary DNA (cDNA)IBA 12/2004 - 10/2002
5	Brain-Derived Neurotrophic Factor (BDNF)IBA 11/2018 - 08/2005
5	Antipsychotic Agents (Antipsychotics)IBA 01/2017 - 06/2006
5	Serotonin (5 Hydroxytryptamine)IBA 01/2017 - 02/2005
5	Cholinesterase Inhibitors (Anticholinesterases)IBA 10/2016 - 06/2004
5	EnzymesIBA 01/2016 - 12/2002
5	Oxyquinoline (8 Hydroxyquinoline)FDA Link 06/2014 - 01/2010
5	Cholinergic Agents (Cholinergics)IBA 07/2012 - 02/2005
5	Proteasome Endopeptidase Complex (Proteasome)IBA 11/2009 - 08/2004
4	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 11/2018 - 11/2009
4	LithiumIBA 04/2013 - 06/2004
4	Selective Serotonin Reuptake Inhibitors (Serotonin Reuptake Inhibitors)IBA 04/2012 - 06/2006
4	methyl carbamateIBA 04/2012 - 10/2002
4	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 01/2012 - 11/2009
4	FlavonoidsIBA 01/2012 - 03/2004
4	Levodopa (L Dopa)FDA LinkGeneric 11/2010 - 01/2005
4	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 11/2009 - 01/2008
4	Catechin (Z 7300)IBA 10/2008 - 08/2004
4	(N-propargyl-(3R) and (3S) aminoindan-5-yl)-ethyl methyl carbamateIBA 06/2004 - 10/2002
3	Glial Cell Line-Derived Neurotrophic Factor (GDNF)IBA 11/2018 - 01/2012
3	Erythropoietin FDA Link 11/2018 - 01/2012
3	Nerve Growth Factors (Neurotrophins)IBA 11/2018 - 01/2012
3	Rivastigmine (Exelon)FDA LinkGeneric 01/2017 - 10/2006
3	Glutamic Acid (Glutamate)FDA Link 02/2016 - 10/2003
3	Ethanol (Ethyl Alcohol)IBA 01/2015 - 08/2009
3	Insulin (Novolin)FDA Link 02/2014 - 11/2009
3	Peroxynitrous Acid (Peroxynitrite)IBA 03/2013 - 11/2007
3	Biomarkers (Surrogate Marker)IBA 05/2012 - 01/2007
3	Free RadicalsIBA 01/2012 - 11/2009
3	Protein AggregatesIBA 01/2011 - 03/2004
3	Messenger RNA (mRNA)IBA 02/2009 - 08/2005
3	Caspase 3 (Caspase-3)IBA 09/2008 - 01/2007
3	neuromelaninIBA 01/2004 - 01/2003
2	AcetylcholinesteraseIBA 01/2022 - 01/2012
2	5- (2- (methylprop- 2- ynylamino)ethyl)quinolin- 8- olIBA 10/2017 - 01/2017
2	Norepinephrine (Noradrenaline)FDA LinkGeneric 01/2017 - 02/2005
2	Scopolamine (Hyoscine)FDA Link 01/2017 - 01/2016
2	AcidsIBA 01/2017 - 05/2011
2	Biological ProductsIBA 10/2016 - 03/2004
2	Acetylcholine (Acetylcholine Chloride)FDA Link 01/2016 - 04/2012
2	Donepezil (Aricept)FDA LinkGeneric 01/2016 - 06/2014
2	Oxidoreductases (Dehydrogenase)IBA 01/2016 - 02/2009
2	Peptides (Polypeptides)IBA 01/2016 - 01/2008
2	LigandsIBA 01/2016 - 09/2011
2	1-Methyl-4-phenylpyridinium (1 Methyl 4 phenylpyridinium)IBA 01/2014 - 11/2009

Therapy/Procedure

16	Therapeutics 01/2022 - 01/2002